Deorphanizing GPCRs
Since the Gq and Gs calcium responses can be differentiated by their kinetic profiles, it is possible to use the ACT:One technology to classify receptors into a Gq or Gs category, thereby assisting in deorphanizing those receptors. Gi receptors can also be investigated. Also, since the signaling is through native receptors and G-proteins, there is no need to have access to the naturally occurring ligand.

HTS Screening
Taking advantage of the live-cell aspects of the ACT:One technology makes it possible to screen for agonists, antagonists and allosteric modulators during a single screen. And, with the excellent data quality, you will have confidence in your screening results.

Basic research on cAMP
The biosensor works by measuring localized cAMP levels within cells making it a cost effective assay for cAMP for basic research applications.