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A scaleable cAMP biosensor HTS platform is a critical part of our drug discovery and deorphanization processes.
ACT:One™ | Cell Lines

Endogenous Gs-coupled receptors in HEK2930-CNG cells.

  • β-adrenoreceptor (likely both β1 & β2)
  • Adenosine A2b
  • Prostaglandin E2

Heterologous Gi-coupled receptors in HEK293-CNG cells.

  • Adenosine A1Adenosine A3
  • Cannabinoid receptor 1
  • Cannabinoid receptor 2
  • Dopamine D2 (DRD2)
  • Endothelial differentiation, sphingolipid G-protein-coupled receptor 1 (EDG1)
  • Glutamate receptor, metabotropic 7
  • Glutamate receptor, metabotropic 8
  • Melanin concentrating hormone 1 (MCHR1)
  • Neuropeptide Y receptor Y1 (NPY1R)
  • Neuropeptide Y receptor Y2 (NPY2R)
  • Somatostatin 5 (SSTR5)

Heterologous Gs-coupled receptors in HEK293-CNG cells.

  • Adenosine A2a
  • Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1)
  • Arginine Vasopressin 2 (AVPR2)
  • Calcitonin (CALCR)
  • Calcitonin-like (CALCRL)
  • Corticotropin Releasing Hormone 1 (CRHR1)
  • Corticotropin Releasing Hormone Receptor 2 (CRHR2)
  • Dopamine 1 (DRD1)
  • Dopamine Receptor 5 (DRD5)
  • Follicle stimulating hormone receptor (FSHR)
  • Glucagon (GCGR)
  • Glucagon-like 1 (GLP1R)
  • Glucagon-like 2 (GLP2R)
  • Gastric inhibitor peptide (GIPR)
  • Melanocortin 1 (MC1R)
  • Melanocortin 3 (MC3R)
  • Melanocortin 4 (MC4R)
  • Melanocortin 5 Receptor (MC5R)
  • Parathyroid Hormone 1 (PTHR1)
  • Parathyroid Hormone Receptor 2 (PTHR2)
  • Prostaglandin E4 (PTGER4)
  • Prostaglandin D2 (PTGDR2)
  • Prostaglandin I2 (PTGIR)
  • Secretin receptor (SCTR)
  • Serotonin Receptor 6 (HTR6)
  • Serotonin Receptor 7 (HTR7B)
  • Thyroid stimulating hormone receptor (TSHR)
  • Vasoactive Intestinal Peptide 1 (VIPR1)
  • Vasoactive Intestinal Peptide 2 (VIPR2)

This list is always expanding. Check with BD if there is something of interest that you don't see here.